Send to

Choose Destination
Clin Infect Dis. 1997 Jan;24 Suppl 1:S19-45.

Evolution and dissemination of beta-lactamases accelerated by generations of beta-lactam antibiotics.

Author information

Miriam Hospital, Brown University, Providence, Rhode Island 02906, USA.


beta-Lactamases are the principal mechanism of bacterial resistance to beta-lactam antibiotics. In recent years the number and variety of new beta-lactamases detected has risen at an alarming rate, apparently in response to the clinical use of novel classes of beta-lactam antibiotics. This paper reviews the structure and evolution of beta-lactamases in an attempt to understand the pressures that have contributed to their emergence.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center