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Clin Infect Dis. 1997 Jan;24 Suppl 1:S19-45.

Evolution and dissemination of beta-lactamases accelerated by generations of beta-lactam antibiotics.

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1
Miriam Hospital, Brown University, Providence, Rhode Island 02906, USA.

Abstract

beta-Lactamases are the principal mechanism of bacterial resistance to beta-lactam antibiotics. In recent years the number and variety of new beta-lactamases detected has risen at an alarming rate, apparently in response to the clinical use of novel classes of beta-lactam antibiotics. This paper reviews the structure and evolution of beta-lactamases in an attempt to understand the pressures that have contributed to their emergence.

[Indexed for MEDLINE]

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