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Clin Cardiol. 1997 Jan;20(1):3-6.

Angiotensin-II-receptors: new targets for antihypertensive therapy.

Author information

1
Duke University Medical Center, Durham, North Carolina, USA.

Abstract

The renin-angiotensin system regulates blood pressure and sodium homeostasis through a series of coordinated substrate-enzyme interactions. These interactions result in the production of angiotensin II (AII), which exerts a number of diverse biologic effects mediated through AII cell-surface receptors. Dysregulation of this system is implicated in the pathogenesis of various forms of hypertension. Traditional therapy for hypertension has included angiotensin-converting enzyme inhibitors, which block the production of AII. However, a new class of drugs, AT1-receptor blockers, now offers a number of benefits by specifically blocking the effects of AII at its physiologically relevant receptor.

PMID:
8994730
PMCID:
PMC6655881
DOI:
10.1002/clc.4960200103
[Indexed for MEDLINE]
Free PMC Article

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