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Immunol Today. 1996 May;17(5):225-31.

IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease.

Author information

1
Dept of Dermatology, Ludwig-Maximilians-University Munich, Germany.

Abstract

Organ-specific autoimmune diseases are mediated by interferon gamma (IFN-gamma)-producing T helper 1 (Th1) cells. Here, Martin Röcken and colleagues review the experimental basis for an antigen-specific therapeutic approach to inflammatory autoimmune diseases. This strategy involves selective deviation of harmful Th1 responses towards an anti-inflammatory, interleukin 4 (IL-4)-producing Th2 phenotype.

PMID:
8991384
[Indexed for MEDLINE]

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