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Immunol Today. 1996 May;17(5):209-12.

Integrins as promiscuous signal transduction devices.

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1
Dept of Biological Sciences, Wayne State University, Detroit, MI 48202, USA.

Abstract

Recent studies suggest physical and functional interactions of glycosylphosphatidylinositol (GPI)-linked proteins (CD14, CD16b and CD87) with leukocyte beta 2 integrins. As discussed in this article, it now appears that beta 2 integrins relay proinflammatory information from GPI-anchored membrane receptors to the cytoplasm via exodomain interactions.

PMID:
8991380
[Indexed for MEDLINE]

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