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Am J Psychiatry. 1997 Jan;154(1):116-8.

Lower levels of nucleoside triphosphate in the basal ganglia of depressed subjects: a phosphorous-31 magnetic resonance spectroscopy study.

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  • 1Brain Imaging Center, McLean Hospital, Belmont, MA 02178, USA.

Abstract

OBJECTIVE:

The purpose of this study was to evaluate whether the concentration of beta-nucleoside triphosphate is lower in the basal ganglia of depressed subjects.

METHOD:

In vivo 31P magnetic resonance spectra were acquired from a 45-cm3 region surrounding the basal ganglia of 35 unmedicated depressed subjects and 18 comparison subjects.

RESULTS:

beta-Nucleoside triphosphate, which arises primarily from beta-ATP, was 16% lower in the depressed subjects than in the comparison subjects.

CONCLUSIONS:

The low level of beta-nucleoside triphosphate is consistent with an abnormality of high-energy phosphate metabolism in the basal ganglia of subjects with major depression.

PMID:
8988971
DOI:
10.1176/ajp.154.1.116
[PubMed - indexed for MEDLINE]
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