Format

Send to

Choose Destination
Trends Biotechnol. 1996 Oct;14(10):369-75.

Identifying structure-function relationships in four-helix bundle cytokines: towards de novo mimetics design.

Author information

1
Department of Medicine, University of Pennsylvania, School of Medicine, Philadelphia 19104-6100, USA. chaiken@mail.med.upenn.edv

Abstract

Many cytokines (growth-factor proteins) are constructed from a common four-helix bundle structural framework. Rapid advances have been made in relating the structure and function of a growing number of four-helix bundle cytokines. This understanding opens the way to design de novo mimetics through such strategies as cytokine hybrids, structure-excerpted scaffolds and contact residue topology mimics. These may provide leads for agonists and antagonists of cell growth and differentiation.

PMID:
8987635
DOI:
10.1016/0167-7799(96)10050-0
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center