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Trends Biochem Sci. 1996 Nov;21(11):413-7.

Structure and function of the protein tyrosine phosphatases.

Author information

1
Biophysics Research Division, University of Michigan, Ann Arbor 48109-1055, USA.

Abstract

The tyrosine and dual-specificity phosphatases are involved in signaling, cell growth and differentiation, and the cell cycle. The enzymes share a common catalytic mechanism mediated by an active site cysteine, arginine and aspartic acid. Supplementary domains assist in targeting and substrate specificity.

PMID:
8987394
DOI:
10.1016/s0968-0004(96)10059-1
[Indexed for MEDLINE]

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