Send to

Choose Destination
See comment in PubMed Commons below
Exp Cell Res. 1996 Dec 15;229(2):212-6.

Genetic analysis of macromolecular transport across the nuclear envelope.

Author information

  • 1Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School and the Dana Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts, 02115, USA.


Numerous factors that promote movement of macromolecules in and out of the nucleus have now been identified. These include both soluble cytoplasmic and nucleoplasmic proteins and proteins of the nuclear pore complex (NPC). Genetic analyses of the nuclear transport process in the model organism, the budding yeast Saccharomyces cerevisiae, have revealed remarkable conservation of all of these factors. In addition, important clues as to how these factors promote the unique bidirectional movement across the NPC have emerged from studies of yeast. We summarize the characterization and genetic interactions of the soluble transport factors and present data to illustrate how genetic experiments can be used to further define the import and export pathways.

[PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center