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Nature. 1997 Jan 2;385(6611):37-41.

Hydrolysis of GTP by elongation factor G drives tRNA movement on the ribosome.

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Institute of Molecular Biology, University of Witten/Herdecke, Germany.


Elongation factor G (EF-G) is a GTPase that is involved in the translocation of bacterial ribosomes along messenger RNA during protein biosynthesis. In contrast to current models, EF-G-dependent GTP hydrolysis is shown to precede, and greatly accelerate, the rearrangement of the ribosome that leads to translocation. Domain IV of the EF-G structure is crucial for both rapid translocation and subsequent release of the factor from the ribosome. By coupling the free energy of GTP hydrolysis to translocation, EF-G serves as a motor protein to drive the directional movement of transfer and messenger RNAs on the ribosome.

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[Indexed for MEDLINE]

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