Format

Send to

Choose Destination
See comment in PubMed Commons below
Annu Rev Genet. 1996;30:603-36.

Tumor suppressor gene mutations in mice.

Author information

1
Howard Hughes Medical Institute, Massachusetts Institute of Technology Center for Cancer Research, Cambridge 02139, USA.

Abstract

Over the past several years, a number of human tumor suppressor genes have been cloned and characterized. Germline mutations in tumor suppressor genes strongly predispose to cancer, and they are also mutated somatically in sporadic forms of the disease. In order to create animal models for the familial cancer syndromes caused by inherited mutations in these genes as well as to determine their role in embryogenesis, the homologues of several members of this class have been mutated in the mouse. The initial characterization of the heterozygous and homozygous phenotypes caused by these mutations has led to important insights into the mechanisms by which tumor suppressor genes participate in normal development and how their loss contributes to tumorigenesis.

PMID:
8982467
DOI:
10.1146/annurev.genet.30.1.603
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon
    Loading ...
    Support Center