Format

Send to

Choose Destination
Annu Rev Genet. 1996;30:529-56.

Paralogous Hox genes: function and regulation.

Author information

1
Division of Developmental Neurobiology, MRC National Institute for Medical Research, London, United Kingdom.

Abstract

The Hox homeobox gene family plays a pivotal role in regulating patterning and axial morphogenesis in vertebrates. Molecular characterization of the four Hox clusters has shown that they are evolutionarily related with respect to sequence, organization, and expression, suggesting they arose by duplication and divergence. Transgenic analysis has clearly demonstrated the functional roles of individual genes in a broad range of embryonic tissues, and in compound mutants has addressed the issues of cooperativity and redundancy. There is an emerging picture of the cis-regulatory elements underlying Hox expression, and for the 3' members of the clusters there is a considerable degree of conservation between paralogous genes with respect to their functional roles and regulatory control.

PMID:
8982464
DOI:
10.1146/annurev.genet.30.1.529
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center