Format

Send to

Choose Destination
Annu Rev Genet. 1996;30:371-403.

Phylogenetic analysis in molecular evolutionary genetics.

Author information

1
Institute of Molecular Evolutionary Genetics, Pennsylvania State University, University Park 16802, USA. NXM2@PSU.EDU

Abstract

Recent developments of statistical methods in molecular phylogenetics are reviewed. It is shown that the mathematical foundations of these methods are not well established, but computer simulations and empirical data indicate that currently used methods such as neighbor joining, minimum evolution, likelihood, and parsimony methods produce reasonably good phylogenetic trees when a sufficiently large number of nucleotides or amino acids are used. However, when the rate of evolution varies extensively from branch to branch, many methods may fail to recover the true topology. Solid statistical tests for examining the accuracy of trees obtained by neighbor joining, minimum evolution, and least-squares method are available, but the methods for likelihood and parsimony trees are yet to be refined. Parsimony, likelihood, and distance methods can all be used for inferring amino acid sequences of the proteins of ancestral organisms that have become extinct.

PMID:
8982459
DOI:
10.1146/annurev.genet.30.1.371
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center