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Indian J Exp Biol. 1996 Jul;34(7):698-701.

Modulation of humoral and cell-mediated immune responses by Azadirachta indica (Neem) in mice.

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Department of Pharmacology, University College of Medical Sciences (University of Delhi), Shahdara, Delhi, India.


The effects of A. indica (AI, Neem) were evaluated on tests of humoral and cell-mediated immune responses after 3 weeks of oral AI (leaf extract) treatment in ovalbumin immunized mice. At the dose levels tested, AI (10, 30 or 100 mg/kg), had no appreciable influence on different organ (liver, spleen, thymus)/body weight indices, when compared to controls. In tests for humoral immune responses, AI (100 mg/kg) treated mice had higher (1) IgM and IgG levels, and (b) anti-ovalbumin antibody titres, when compared to the vehicle treated group. In tests for cell-mediated immune responses, there was an enhancement (%) of (a) macrophage migration inhibition, and (b) footpad thickness after AI (100 mg/kg) treatment. These results are discussed in light of the possible immunopotentiating effects of AI.

[Indexed for MEDLINE]

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