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Prostate. 1996 Dec;29(6):350-5.

Regulation of S100P expression by androgen.

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1
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, USA.

Abstract

BACKGROUND:

The growth and function the normal prostate is dependent on the presence of androgen. As prostate tumors progress there is a loss of androgen-dependent cell growth. The identification of the genes that are regulated by androgens may be of pathological and clinical significance.

METHODS:

In this study the differential display method was used to identify genes regulated by androgen in an androgen-responsive prostate cancer cell line, LNCaP-FGC.

RESULTS:

A gene whose expression is down-regulated in LNCaP-FGC cells after 30 hr of androgen deprivation has been identified. This gene is a previously identified member of the S100 gene family of calcium-binding proteins, namely S100P. Here we show that S100P expression is regulated by the synthetic androgen R1881, but not by serum growth factors. It is dysregulated in the androgen-independent prostate cancer cell lines LNCaP-R, DU145, and PC3.

CONCLUSIONS:

The data indicate that S100P may play a role in the etiology of prostate cancer.

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