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J Exp Med. 1996 Dec 1;184(6):2411-6.

Ceramide inhibits antigen uptake and presentation by dendritic cells.

Author information

1
Department of Immunology, Istituto Superiore di Sanità, Rome, Italy.

Abstract

Ceramides are intramembrane diffusible mediators involved in transducing signals originated from a variety of cell surface receptors. Different adaptive and differentiative cellular responses, including apoptotic cell death, use ceramide-mediated pathways as an essential part of the program. Here, we show that human dendritic cells respond to CD40 ligand, as well as to tumor necrosis factor-alpha and IL-1 beta, with intracellular ceramide accumulation, as they are induced to differentiate. Dendritic cells down-modulate their capacity to take up soluble antigens in response to exogenously added or endogenously produced ceramides. This is followed by an impairment in presenting soluble antigens to specific T cell clones, while cell viability and the capacity to stimulate allogeneic responses or to present immunogenic peptides is fully preserved. Thus, ceramide-mediated pathways initiated by different cytokines can actively modulate professional antigen-presenting cell function and antigen-specific immune responses.

PMID:
8976196
PMCID:
PMC2196395
[Indexed for MEDLINE]
Free PMC Article

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