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Annu Rev Cell Dev Biol. 1996;12:161-80.

Organizing spatial pattern in limb development.

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European Molecular Biology Laboratory, Heidelberg, Germany.


Recent studies on the development of the legs and wings of Drosophila have led to the conclusion that insect limb development is controlled by localized pattern organizing centers, analogous to those identified in vertebrate embryos. Genetic analysis has defined the events that lead to the formation of these organizing centers and has led to the identification of gene products that mediate organizer function. The possibility of homology between vertebrate and insect limbs is considered in light of recently reported similarities in patterns of gene expression and function.

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