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Bioessays. 1996 Apr;18(4):301-8.

Chromosome healing: spontaneous and programmed de novo telomere formation by telomerase.

Author information

1
Department of Biochemistry and Biophysics, Texas A&M University, College Station 77843-2128, USA.

Abstract

Telomeres are protective caps for chromosome ends that are essential for genome stability. Broken chromosomes missing a telomere will not be maintained unless the chromosome is 'healed' with the formation of a new telomere. Chromosome healing can be a programmed event following developmentally regulated chromosome fragmentation, or it may occur spontaneously when a chromosome is accidentally broken. In this article we discuss the consequences of telomere loss and the possible mechanisms that the enzyme telomerase employs to form telomeres de novo on broken chromosome ends.

PMID:
8967898
DOI:
10.1002/bies.950180408
[Indexed for MEDLINE]
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