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Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14800-3.

The mutation rate and cancer.

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1
Cancer Genetics Laboratory, Imperial Cancer Research Fund, London, United Kingdom.

Abstract

The selection of advantageous mutations underlies tumorigenesis. The growth of a tumor is therefore a form of evolution at the somatic level, in which the population is comprised of individual cells within the tumor. Models of tumorigenesis have considered the relative importance of mutation and selection. We show that selection is more important than an increased mutation rate in the growth of a tumor. Some cancers may acquire a "mutator phenotype," probably leading to faster growth, but mutator phenotypes are not necessary for carcinogenesis.

PMID:
8962135
PMCID:
PMC26216
[Indexed for MEDLINE]
Free PMC Article
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