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Infect Dis Clin North Am. 1996 Dec;10(4):693-707.

Overwhelming postsplenectomy infection.

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Division of Infectious Diseases, New Jersey Medical School, Newark, USA.


The incidence of overwhelming sepsis in asplenic patients is low. It carries, however, an unacceptably high morbidity rate and mortality rate. The risk of development is related to the age of the patient as well as the duration since and the reason for splenectomy. It may also occur in functionally hyposplenic states. The rapidly lethal clinical course demands intense efforts toward prevention by both physician and patient, rapid recognition within the initial medical setting, and aggressive intervention with broad-spectrum antibiotics and other supportive measures.

[Indexed for MEDLINE]

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