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Brain Res. 1996 Nov 4;738(2):353-6.

Effects of an AMPA receptor modulator on methamphetamine-induced hyperactivity in rats.

Author information

1
Center for the Neurobiology of Learning and Memory, University of California, Irvine 92697, USA.

Abstract

The present study tested if a positive modulator of AMPA-type glutamate receptors would counteract the behavioral effects of a drug that enhances the release of dopamine. BDP-29, a compound shown to increase AMPA receptor-mediated synaptic responses in hippocampal slices, markedly attenuated the amount of stereotypic rearings seen in rats after methamphetamine injections. These results suggest that AMPA receptor modulators ameliorate certain aberrant, dopamine-related behaviors and hence may be of interest with regard to schizophrenia.

PMID:
8955535
DOI:
10.1016/s0006-8993(96)01049-9
[Indexed for MEDLINE]

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