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Mol Med Today. 1996 Nov;2(11):482-9.

Interleukin 8 as a novel target for intervention therapy in acute inflammatory diseases.

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Department of Hygiene, School of Medicine, Kanazawa University, Ishikawa, Japan.


Aberrant production of interleukin 8 (IL-8) has been shown in various human inflammatory diseases. Recent investigations in animal models using either blocking antibodies against IL-8 or disruption of the gene encoding the IL-8 receptor have revealed the involvement of IL-8 in the recruitment of neutrophils and in neutrophil-associated tissue injury in acute inflammation. These studies suggest that IL-8 is a novel target to alleviate acute inflammation. This review describes the properties of IL-8 and discusses different therapeutic approaches to target IL-8, particularly the use of humanized monoclonal antibodies against IL-8 and inhibition of IL-8 gene transcription.

[Indexed for MEDLINE]

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