Format

Send to

Choose Destination
Nature. 1996 Dec 5;384(6608):432-8.

Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction.

Author information

1
Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA.

Abstract

The human cytomegalovirus genome encodes proteins that trigger destruction of newly synthesized major histocompatibility complex (MHC) class I molecules. The human cytomegalovirus gene US2 specifies a product capable of dislocating MHC class I molecules from the endoplasmic reticulum to the cytosol and delivering them to the proteasome. This process involves the Sec61 complex, in what appears to be a reversal of the reaction by which it translocates nascent chains into the endoplasmic reticulum.

PMID:
8945469
DOI:
10.1038/384432a0
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center