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Science. 1996 Dec 13;274(5294):1906-9.

CD5-mediated negative regulation of antigen receptor-induced growth signals in B-1 B cells.

Author information

1
Department of Microbiology and Immunology and Center on Aging, University of Kentucky, Lexington, KY 40536, USA. sbonda@pop.uky.edu

Abstract

A subset of B lymphocytes present primarily in the peritoneal and pleural cavities is defined by the expression of CD5 and is elevated in autoimmune diseases. Upon signaling through membrane immunoglobulin M (mIgM), splenic B lymphocytes (B-2) proliferate, whereas peritoneal B cells (B-1) undergo apoptosis. However, in CD5-deficient mice, B-1 cells responded to mIgM crosslinking by developing a resistance to apoptosis and entering the cell cycle. In wild-type B-1 cells, prevention of association between CD5 and mIgM rescued their growth response to mIgM crosslinking. Thus the B cell receptor-mediated signaling is negatively regulated by CD5 in normal B-1 cells.

PMID:
8943203
DOI:
10.1126/science.274.5294.1906
[Indexed for MEDLINE]

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