Send to

Choose Destination
Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13445-52.

Toward a molecular definition of long-term memory storage.

Author information

Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia, University, New York State Psychiatric Institute, NY 10032, USA.


The storage of long-term memory is associated with a cellular program of gene expression, altered protein synthesis, and the growth of new synaptic connections. Recent studies of a variety of memory processes, ranging in complexity from those produced by simple forms of implicit learning in invertebrates to those produced by more complex forms of explicit learning in mammals, suggest that part of the molecular switch required for consolidation of long-term memory is the activation of a cAMP-inducible cascade of genes and the recruitment of cAMP response element binding protein-related transcription factors. This conservation of steps in the mechanisms for learning-related synaptic plasticity suggests the possibility of a molecular biology of cognition.

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center