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FEBS Lett. 1996 Nov 11;397(1):117-21.

Evidence for a novel regulatory pathway activated by (carba)prostacyclin in preadipose and adipose cells.

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Centre de Biochimie du CNRS (UMR 134), Université de Nice-Sophia Antipolis, Faculté des Sciences, Nice, France.


Prostacyclin, one of the major prostanoids generated in adipose tissue, has been previously described as an autocrine/paracrine adipogenic effector, acting, in preadipose cells, by means of cAMP and free Ca2+ as cell surface receptor-mediated messengers. The present study presents evidence for the first time that its stable analogue, carbaprostacyclin, is unique among prostanoids in regulating the expression of two differentiation-dependent genes in preadipose and adipose cells in a way distinct from that elicited by its cell surface receptor. This regulation is likely mediated by some member(s) of the peroxisome proliferator-activated receptor family and suggests that prostacyclin behaves as an intracrine effector of adipose cell differentiation.

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