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FEBS Lett. 1996 Nov 11;397(1):50-4.

Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells.

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Institute for Brain Aging and Dementia, University of California, Irvine 92697-4540, USA.


Presenilin-2 is a gene of unknown function recently identified based upon linkage with some forms of familial Alzheimer's disease. To investigate potential effects of PS-2 on cell viability, rat pheochromocytoma (PC12) cells were stably transfected with cDNA constructs encoding either full-length human PS-2 or, for comparison, mouse Bcl-X(L). Overexpression of PS-2 conferred increased sensitivity to the apoptotic stimuli staurosporine and hydrogen peroxide. In contrast, Bcl-X(L) overexpression significantly reduced cell death induced by these stimuli. These results suggest that one function of PS-2 may involve modulation of cell viability.

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