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Biochem Biophys Res Commun. 1996 Nov 21;228(3):752-6.

A novel heme protein that acts as a carbon monoxide-dependent transcriptional activator in Rhodospirillum rubrum.

Author information

1
School of Materials Science, Japan Advanced Institute of Science and Technology, Ishikawa, Japan. aono@jaist.ac.jp

Abstract

The gene coding for a carbon monoxide-dependent transcriptional activator (cooA) in Rhodospirillum rubrum has been expressed in E. coli, and the recombinant CooA has been purified. CooA contains b-type heme which may act as a CO sensor in vivo. CO-bound CooA was formed when reduced CooA was reacted with CO, but not in the case of oxidized CooA. CooA is the first example of the heme protein acting as a DNA-binding transcriptional activator.

PMID:
8941349
DOI:
10.1006/bbrc.1996.1727
[Indexed for MEDLINE]

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