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Science. 1996 Dec 6;274(5293):1739-44.

Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV.

Author information

1
School of Public Health, Columbia University, New York, NY 10032, USA.

Abstract

Four virus proteins similar to two human macrophage inflammatory protein (MIP) chemokines, interleukin-6 (IL-6), and interferon regulatory factor (IRF) are encoded by the Kaposi's sarcoma-associated herpesvirus (KSHV) genome. vIL-6 was functional in B9 proliferation assays and primarily expressed in KSHV-infected hematopoietic cells rather than KS lesions. HIV-1 transmission studies showed that vMIP-I is similar to human MIP chemokines in its ability to inhibit replication of HIV-1 strains dependent on the CCR5 co-receptor. These viral genes may form part of the response to host defenses contributing to virus-induced neoplasia and may have relevance to KSHV and HIV-I interactions.

PMID:
8939871
[Indexed for MEDLINE]

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