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Curr Opin Cell Biol. 1996 Dec;8(6):767-72.

The dynamics of cyclin dependent kinase structure.

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1
Department of Physiology, Box 0444, University of California, 513 Parnassus Ave, San Francisco, CA 94143, USA. dmorgan@socrates.ucsf.edu

Abstract

In the past year, several new crystal structures have provided exciting insights into the conformational changes underlying the regulation of cyclin-dependent kinases. We now understand the structural basis of many of the mechanisms by which cyclin-dependent kinases are regulated, including activation by cyclin binding and phosphorylation, inhibition by the inhibitor p27, and binding by the CKS proteins.

PMID:
8939669
[Indexed for MEDLINE]
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