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Curr Opin Cell Biol. 1996 Dec;8(6):815-21.

Cell cycle control of replication initiation in eukaryotes.

Author information

1
Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Hertfordshire, EN6 3LD, UK. chevalie@icrf.icnet.uk

Abstract

Studies on the initiation of DNA replication in eukaryotes have progressed recently through different approaches that promise to converge. Proteins interacting with the origin recognition complex form a prereplicative complex early in the cell cycle. The regulation of the binding of MCM/P1 proteins to chromatin plays a key role in the replication licensing system which prevents re-replication in a single cell cycle. Cyclin-dependent kinases provide an overall control of the cell cycle by stimulating S-phase entry and possibly by preventing re-establishment of prereplicative complexes in G2 phase.

PMID:
8939667
DOI:
10.1016/s0955-0674(96)80082-2
[Indexed for MEDLINE]

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