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Curr Opin Cell Biol. 1996 Oct;8(5):724-30.

Integrins and cancer.

Author information

1
Department of Medicine, University of California, San Diego, University Center 303, 9500 Gilman Drive, La Jolla, CA 92093-0063, USA. jvarner@ucsd.edu

Abstract

The past year or two has seen great advances in the elucidation of significant roles for integrins in cancer cells. These include roles in signal transduction, gene expression, proliferation, apoptosis regulation, invasion and metastasis, and angiogenesis. In particular, integrin alphavbeta3 has been implicated in the neovascularization of tumors. In addition, this integrin has been shown to contribute to the survival, proliferation and metastatic phenotype of human melanoma.

PMID:
8939661
DOI:
10.1016/s0955-0674(96)80115-3
[Indexed for MEDLINE]

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