Format

Send to

Choose Destination
Curr Opin Cell Biol. 1996 Oct;8(5):692-9.

ADAMs and cell fusion.

Author information

1
Department of Cell Biology, University of Virginia Health Sciences Center, PO Box 439, Charlottesville, VA 22908, USA. jw7g@virginia.edu

Abstract

Members of the ADAM family (membrane proteins with a disintegrin and metalloprotease domain) have been implicated in several cell-interactive events, including cell-cell fusion. Recent evidence implicates three ADAMs, fertilin-alpha, fertilin-beta, and meltrin-alpha, in sperm-egg fusion and myoblast fusion. In light of the large number and wide tissue distribution of the ADAMs, they may also participate in other cell-cell fusion events. As ADAMs are also found in both vertebrates and invertebrates, some features of cell-cell fusion reactions may be conserved throughout the animal kingdom.

PMID:
8939659
DOI:
10.1016/s0955-0674(96)80111-6
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center