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Curr Opin Cell Biol. 1996 Oct;8(5):609-17.

Extracellular calcium-binding proteins.

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Institute for Biochemistry, Medical Faculty, University of Köln, Joseph-Stelzmann-Strasse 52, 50931 Köln, Germany.


Point mutations in Ca2+-binding sites of extracellular matrix proteins have been identified as the cause of human disorders such as Marfansyndrome and pseudoachondroplasia. Although the modes of Ca2+ binding and the effects of point mutations are not yet understood in these two cases, new insight was recently gained by X-ray and NMR structure determinations of several other extracellular proteins; these studies revealed a diversity of functions of Ca2+ ions. Ca2+ may induce a profound conformational change within a single domain, may bridge adjacent domains and thus direct the relative domain orientation and supramolecular structure, or may be involved in carbohydrate and membrane binding.

[Indexed for MEDLINE]

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