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Curr Opin Biotechnol. 1996 Dec;7(6):653-8.

Toward the development of DNA vaccines.

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Department of Virus Biology, Merck Research Laboratories, WP 16-10,1 West Point, PA 19486, USA.


DNA vaccination has proved to be a generally applicable technology in various preclinical animal models of infectious and noninfectious disease and several DNA vaccines have now entered phase I human clinical trials. It is too early to predict the effectiveness of DNA vaccines in humans and whether improved formulations of DNA vaccines will be required but several lines of investigation have suggested ways in which DNA vaccines may be improved, such as increases in expression, facilitation of DNA targeting or uptake, and enhancement of immune responses.

[Indexed for MEDLINE]

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