Myeloma stem cells in autografting in multiple myeloma

J Hematother. 1996 Oct;5(5):557-9. doi: 10.1089/scd.1.1996.5.557.

Abstract

Autologous transplantation has been used increasingly over the last 10 years for the treatment of multiple myeloma. As is the case in other cancers treated by high-dose therapy and stem cell rescue, the contribution of occult tumor cells in the graft to relapse posttransplant remains to be resolved. In this report, we review the biology and differentiation of plasma cells in the context of their significance as an origin of relapse in multiple myeloma.

Publication types

  • Review

MeSH terms

  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Multiple Myeloma* / pathology
  • Multiple Myeloma* / therapy
  • Neoplastic Stem Cells / pathology*
  • Recurrence
  • Transplantation, Autologous