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J Antimicrob Chemother. 1996 Oct;38(4):579-87.

The effects of antifungal agents on the morphogenetic transformation by Candida albicans in vitro.

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Lepetit Research Center, Marion Merrell Dow Research Institute, Varese, Italy.


The effects of antifungal agents, with different mechanisms of action, on the morphogenetic transformation by synchronised yeast-phase Candida albicans cells in vitro and their respective anti-Candida activities are described. MIC data demonstrated that the azoles, amphotericin B and echinocandin were the most active agents against four C. albicans strains. Morphogenetic transformation experiments demonstrated that amphotericin B was significantly better at preventing the transformation, under a variety of test conditions, than the azoles and flucytosine: amphotericin B abolished the transformation at low concentrations while the azoles only prevented the morphogenetic transformation at much higher concentrations (> 100 x MIC).

[Indexed for MEDLINE]

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