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Curr Opin Neurobiol. 1996 Oct;6(5):667-72.

Ischemia-induced neuronal apoptosis.

Author information

1
Center for the Study of Nervous System Injury, Washington University School of Medicine, St Louis, Missouri 63110-1093, USA.

Abstract

Hypoxic-ischemic neuronal death has long been considered to represent necrosis, but it now appears that many brain neurons undergo apoptosis after either global or focal ischemic insults. This event is probably substantially distinct from ischemia-triggered excitotoxicity, which tends to produce necrosis. While many questions remain unanswered, the concept of ischemic apoptosis has raised exciting prospects of combining anti-apoptotic with anti-excitotoxic treatments to achieve heightened therapeutic benefits in the brains of patients traumatized by cardiac arrest or stroke.

PMID:
8937832
DOI:
10.1016/s0959-4388(96)80101-2
[Indexed for MEDLINE]

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