Format

Send to

Choose Destination
Br J Pharmacol. 1996 Nov;119(6):1081-3.

Nociceptin induced inhibition of K+ evoked glutamate release from rat cerebrocortical slices.

Author information

1
University Department of Anaesthesia, Leicester Royal Infirmary.

Abstract

Nociceptin, an endogenous ligand for the orphan receptor ORL1, has recently been described. In this study we have shown that nociception inhibits 46 mM K(+)-stimulated glutamate release from rat perfused cerebrocortical slices with an IC50 of 51 nM. At 100 nM the inhibition amounted to 68 +/- 14% and was naloxone (10 microM)-insensitive excluding an activation of mu, delta and kappa opioid receptors. These data demonstrate the functional coupling of ORL1 in glutamatergic neurones and implicates a role for nociceptin in glutamatergic neurotransmission.

PMID:
8937708
PMCID:
PMC1915895
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center