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Fluoxetine treatment of children with selective mutism: an open trial.

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1
New York State Psychiatric Institute, Columbia University, New York, USA.

Abstract

OBJECTIVE:

A pilot study was designed to evaluate the safety and efficacy of fluoxetine treatment for children with selective mutism (elective mutism in DSM-III-R).

METHOD:

Twenty-one children (mean age 8.2 years, range 5 through 14) participated in a 9-week open trial of fluoxetine in graduated doses (mean end dose 28.1 mg, range 10 to 60 mg) with systematic baseline and outcome evaluations and weekly clinical assessment.

RESULTS:

All 21 children met DSM-III-R and DSM-IV criteria for anxiety disorders. After fluoxetine treatment, 76% were improved, with diminished anxiety and increased speech in public settings, including school. Improvement at week 9 was inversely correlated with age.

CONCLUSIONS:

Persistent selective mutism presenting with comorbid anxiety disorders may respond to fluoxetine treatment.

[Indexed for MEDLINE]

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