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Anesth Prog. 1995;42(3-4):113-5.

Serum levels of articaine 2% and 4% in children.

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Privatuniversität Witten, Germany.


The results of the present study of the pharmacokinetics of articaine in children show serum concentrations comparable to those in adults. The maximum values are distinctly lower with the 2% articaine solution. The t max found in our investigation was distinctly earlier than in comparable investigations on adults, whereas the plasma clearance was increased. There is no need to fix a lower mg/kg articaine dose limit for children because of age-related differences in the pharmacokinetics. The use of 2% articaine in pediatric dentistry is particularly advantageous because of the lower C max and the shorter half-life.

[Indexed for MEDLINE]
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