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Nature. 1996 Nov 28;384(6607):364-7.

Dendritic cells capable of stimulating T cells in germinal centres.

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Schering-Plough, Laboratory for Immunological Research, Dardilly, France.


The B cells within the germinal centres of lymphoid organs undergo affinity maturation of their antigen receptors, a critical event for antibody memory. Follicular dendritic cells within the germinal centres retain immune complexes that select the developing B cells for which they have a higher affinity. We have now identified a subset of CD4+ CD11c+ CD3- dendritic cells in the germinal centres. These are strong antigen-presenting cells for T cells, but do not co-stimulate CD40-activated B cells. These dendritic cells probably stimulate germinal centre T cells and aid the complicated processes that are required for the generation of memory B cells.

[Indexed for MEDLINE]

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