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Hum Gene Ther. 1996 Nov 10;7(17):2195-200.

Tissue-engineered skeletal muscle organoids for reversible gene therapy.

Author information

1
Department of Pathology, Brown University School of Medicine, Providence, RI 02906, USA.
2
Brown U, Providence, RI

Abstract

Genetically modified murine skeletal myoblasts were tissue engineered in vitro into organ-like structures (organoids) containing only postmitotic myofibers secreting pharmacological levels of recombinant human growth hormone (rhGH). Subcutaneous organoid implantation under tension led to the rapid and stable appearance of physiological sera levels of rhGH for up to 12 weeks, whereas surgical removal led to its rapid disappearance. Reversible delivery of bioactive compounds from postmitotic cells in tissue engineered organs has several advantages over other forms of muscle gene therapy.

PMID:
8934233
DOI:
10.1089/hum.1996.7.17-2195
[Indexed for MEDLINE]

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