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Biochem Mol Biol Int. 1996 Feb;38(1):15-20.

Catalytic center quest: comparison of transposases belonging to the Tn3 family reveals an invariant triad of acidic amino acid residues.

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Institute of Molecular Genetics, Russian Academy of Sciences, Moscow.


Amino acid sequence comparison of transposases belonging to the Tn3 family demonstrates that most of them cluster around three well known transposons, Tn21, Tn3, and Tn917. Eleven amino acid residues, including a triad of acidic residues, are invariant in the COOH-terminal third of the transposase protein while only five residues are invariant in the rest of the protein. We suggest that the invariant triad of Asp689, Asp765, Glu895 (numbering as in Tn3) may correspond to the D-D-35-E motif previously implicated in the catalytic performance of numerous transposases.

[Indexed for MEDLINE]

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