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Science. 1996 Nov 29;274(5292):1527-31.

Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region.

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1
Department of Psychiatry, University of Würzburg, Füchsleinstrasse 15, 97080 Würzburg, Germany. kplesch@rzbox.uni-wuerzburg.de

Abstract

Transporter-facilitated uptake of serotonin (5-hydroxytryptamine or 5-HT) has been implicated in anxiety in humans and animal models and is the site of action of widely used uptake-inhibiting antidepressant and antianxiety drugs. Human 5-HT transporter (5-HTT) gene transcription is modulated by a common polymorphism in its upstream regulatory region. The short variant of the polymorphism reduces the transcriptional efficiency of the 5-HTT gene promoter, resulting in decreased 5-HTT expression and 5-HT uptake in lymphoblasts. Association studies in two independent samples totaling 505 individuals revealed that the 5-HTT polymorphism accounts for 3 to 4 percent of total variation and 7 to 9 percent of inherited variance in anxiety-related personality traits in individuals as well as sibships.

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PMID:
8929413
[Indexed for MEDLINE]

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