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Arch Neurol. 1996 Jul;53(7):678-80.

Proton magnetic resonance spectroscopy of vascular- and Alzheimer-type dementia.

Author information

1
Department of Neurology, University of New Mexico School of Medicine, Albuquerque, USA.

Abstract

OBJECTIVE:

To identify biochemical differences in brain tissue between patients with dementia of the Alzheimer type and vascular dementia.

DESIGN AND SUBJECTS:

Proton magnetic resonance spectroscopy was used to compare 10 patients with dementia of the Alzheimer type and 8 age-matched patients with vascular dementia.

RESULTS:

The ratios of N-acetyl groups to creatine and N-acetyl groups to choline were lower in regions of subcortical white matter in patients with vascular dementia than in patients with dementia of the Alzheimer type (P < .02).

CONCLUSION:

Proton magnetic resonance spectroscopy may be useful in distinguishing between dementia of the Alzheimer type and vascular dementia.

[Indexed for MEDLINE]

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