Format

Send to

Choose Destination
See comment in PubMed Commons below
AIDS. 1996 Jan;10(1):77-80.

High risk of HIV disease progression after infection through a sexual partner with AIDS.

Author information

1
INSERM U-292, Department of Pubic Health, Epidemiology and Human Reproduction, Paris, France.

Abstract

OBJECTIVE:

To investigate whether HIV-1 infection acquired through a severely immunodepressed sexual partner increases the risk of disease progression.

DESIGN:

A prospective cohort of patients infected through sexual contact at a known date and enrolled a few months (median, 2 months) after their first HIV-positive test. At enrolment, 12 subjects stated having had unprotected intercourse (anal or vaginal penetration) with a partner with AIDS within the 6 months prior to their first HIV-positive test. For the same period, 60 subjects stated having had unprotected intercourse with a partner, known to be HIV-positive, but who had not developed AIDS.

METHOD:

The endpoint was the first occurrence of an HIV-related illness (group IV or AIDS, 1987 Centers for Disease Control and Prevention revised classification). Event-free survival curves since infection were constructed using the Kaplan-Meier method and compared by the log-rank test. The Cox model was used for multivariate analysis.

RESULTS:

Disease progression was more rapid among the 12 subjects who stated having sex with a person with AIDS at a time close to infection, than among the other subjects (P = 0.03). Homosexuality and age at infection were also related to HIV disease progression. The adjusted relative risk of developing an HIV-related illness among those 12 subjects was 3.9 (95% confidence interval, 1.5-9.9).

CONCLUSION:

Our results confirm the influence of virus-related factors on the onset of immunodepression in subjects infected through sexual contact.

PMID:
8924255
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center