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Genomics. 1996 Oct 15;37(2):257-9.

Human thioredoxin reductase gene localization to chromosomal position 12q23-q24.1 and mRNA distribution in human tissue.

Author information

1
Arizona Cancer Center, University of Arizona, Tucson 85724-5024, USA.

Abstract

Thioredoxin reductase is a member of the pyridine nucleotide-disulfide oxidoreductase family of enzymes. By delivering reducing equivalents to thioredoxin, thioredoxin reductase exerts control over a number of redox-sensitive factors in the cell, including ribonucleotide reductase and several transcription factors. We have localized the human thioredoxin gene to chromosomal position 12q23-q24.1 by in situ hybridization. We have also determined the relative tissue distribution of thioredoxin reductase mRNA as well as thioredoxin mRNA by probing a Northern blot of several human normal tissues.

PMID:
8921404
DOI:
10.1006/geno.1996.0554
[Indexed for MEDLINE]

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