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Genomics. 1996 Oct 15;37(2):253-6.

Molecular cloning of a novel human gene (D11S4896E) at chromosomal region 11p15.5.

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Department of Haematology and Oncology, Royal Children's Hospital, Parkville, Victoria, Australia.


A novel gene (GOK) has been cloned from human chromosome region 11p15.5 that is believed to contain a gene or genes associated with a number of pediatric malignancies, including Wilms tumor. A 4-kb cDNA has been cloned and it encodes a predicted protein of approximately 84 kDa that could be translated in vitro. Computer analysis predicted that the protein had a signal peptide and may contain a transmembrane helix. Restriction mapping by pulsed-field electrophoresis indicates that GOK is located 1.7 kb telomeric of RRM1, and both genes are transcribed in the same direction. GOK displays high evolutionary conservation: cloning and partial sequencing of a mouse genomic clone revealed 90% identity with the human gene at both the nucleotide and the predicted amino acid levels.

[Indexed for MEDLINE]

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