Using multiple regression analysis, this study examined the contribution of demographic, job-related, social-support, and caregiving variables to the prediction of work-family conflict, stress, and job satisfaction among a sample of 101 hospital-based nurses who had responsibility for the care of a child and/or an elderly relative. The results revealed that family support, perceived organizational support for family life, perceived workload size, and involvement in child care were mainly responsible for the outcomes studied. In addition, the study underscores the importance of separately measuring both the source and the direction of work-family conflict.