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Nature. 1996 Nov 21;384(6606):261-3.

Regulation of an extrathymic T-cell development pathway by oncostatin M.

Author information

1
Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, Washington 98121, USA. christopher_h._clegg@ccmail.bms.com

Abstract

Most of the T lymphocytes that populate the immune system develop in the thymus before its involution during late adolescence. Therefore, subsequent losses in T cells caused by HIV infection, chemotherapy or age-related factors can greatly diminish immune responses to new antigenic challenge. Here we report the discovery of a thymus-independent pathway of T-cell development that may provide help for T-cell immunodeficiency. We show that expression of an oncostatin M transgene in the early T lineage stimulates a dramatic accumulation of immature and mature T cells in lymph nodes. A functional thymus is not required for this effect as reconstitution of nu/nu mice with transgenic bone marrow stimulated a 500-fold increase in Thy-1+ lymph node cells and restored immune responsiveness to allogeneic mouse melanoma cells. This lymphopoietic pathway is not unique to transgenic mice because administration of oncostatin M protein produced a similar response in non-transgenic mice. These results identify a new pathway of T-cell development and a potential treatment for T-cell immunodeficiency with oncostatin M.

PMID:
8918875
DOI:
10.1038/384261a0
[Indexed for MEDLINE]

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